Empirical antifungal therapy in neutropenic patients
نویسندگان
چکیده
منابع مشابه
Empirical antifungal therapy in treating febrile neutropenic patients.
Persistent or recurrent unexplained fever in neutropenic patients receiving antibiotics can be caused by invasive fungal infections, which are often difficult to diagnose. Early trials of empirical antifungal therapy with amphotericin B deoxycholate (AmB) documented reductions in the frequency of and the morbidity and mortality associated with invasive fungal infections. Because of AmB's infusi...
متن کاملPreemptive antifungal therapy among neutropenic patients.
lated from sputum samples obtained from 7 patients were not considered to represent systemic infection. Five (16%) of the patients with VRE bacteremia had polymicrobial infections with Stenotrophomonas maltophilia (2 patients), Escherichia coli (1), Pseudomonas aeruginosa (1), and Staphylococcus aureus (1). Most patients (71%) were neutropenic (absolute neutrophil count, !500 cells/mL) when the...
متن کاملIntravenous Itraconazole vs. Amphotericin B Deoxycholate for Empirical Antifungal Therapy in Patients with Persistent Neutropenic Fever
BACKGROUND Amphotericin B dexoycholate is currently the standard empirical antifungal therapy for neutropenic patients with hematologic malignancies and who also have persistent fever that does not respond to antibacterial therapy. The antifungal triazoles offer a potentially safer and effective treatment alternative to Amphotericin B dexoycholate. METHODS We assessed the efficacy and safety ...
متن کاملEmpirical versus preemptive antifungal therapy for high-risk, febrile, neutropenic patients: a randomized, controlled trial.
BACKGROUND Empirical antifungal therapy is the standard of care for neutropenic patients with hematological malignancies who remain febrile despite broad-spectrum antibacterial treatment. Recent diagnostic improvements may ensure the early diagnosis of potentially invasive fungal disease. Reserving antifungals for this stage may achieve similar survival rates and reduce treatment toxicity and c...
متن کاملEmpiric Antifungal Therapy for the Neutropenic Patient
Among the most significant complications a neutropenic patient can experience is an invasive fungal infection. In this issue of Oncology, Drs. Wingard and Leather thoroughly review the epidemiology, clinical presentation, and empiric treatment of these infections, particularly those associated with Candida and Aspergillus. They emphasize the need for better methods of identifying individuals at...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1984
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/13.5.409